Itch might show swelling in main centrifugal cicatricial alopecia

March 17, 2023

1 minutes read


Gadre A, et al. Examining pruritus as a dependable marker of swelling in CCCA: an observational research study. Provided at Skin of Color Society Scientific Seminar; March 16, 2023; New Orleans.

Gadre reports no pertinent monetary disclosures.

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Secret takeaways:

  • Central centrifugal cicatricial alopecia (CCCA) is a scarring baldness that primarily impacts Black females.
  • Greater levels of interleukin-1B were related to increased itch in clients with CCCA.

BRAND-NEW ORLEANS– Pruritus might be a dependable sign of swelling in main centrifugal cicatricial alopecia, according to a poster provided here.

“[Central centrifugal cicatricial alopecia (CCCA)] is a kind of scarring baldness that predominately impacts black females,” Aditi Gadre, MS, the 2022-2023 Ethnic Skin Research Study Fellow at Johns Hopkins University and the research study’s lead author, informed Healio. “Anecdotally, clients typically can be found in with itching, so we wished to comprehend whether that signifies swelling.”

Alopecia 2
Pruritus might be a dependable sign of swelling in main centrifugal cicatricial alopecia. Image: Adobe Stock.

The scientists carried out noninvasive tape removing in 23 Black females with CCCA and 26 control clients who were each stratified by itch frequency and hair cleaning frequency.

More scalp pruritus was reported in the clients with CCCA compared to the control group, although the distinction was not statistically substantial.

Cytokine expression was evaluated and clients with CCCA and increased scalp pruritus were related to greater levels of interleukin (IL) -1 B, whereas scalp pruritus was not related to any cytokines evaluated in the control clients.

Lower IL-1RA levels were related to shampooing frequency; nevertheless, shampooing frequency was not related to scalp pruritus in clients with CCCA.

” We need to actually focus when somebody with CCCA who has itching is available in grumbling about that as an indication of continuous swelling,” Gadre informed Healio. “If a lady who has actually understood CCCA is available in with a scratchy scalp, that might suggest their illness may be active and we can go on and provide steroid injections or think about stepping up treatment even more.”

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